Skyec Tick Free Spot On for Dogs - Fipronil 9.8% + (S)-Methoprene 8.8% Monthly Topical Tick and Flea Treatment for All Breed Sizes (Up to 10kg to 40–60kg)

Skyec Tick Free SpotOn is a monthly topical spot-on tick and flea treatment for dogs containing Fipronil 9.8% w/v and (S)-Methoprene 8.8% w/v - the same dual-active ingredient combination used in Frontline Plus, manufactured by SkyEC Drugs and Pharmaceuticals Pvt. Ltd., Tamil Nadu. It kills adult fleas within 24 hours, ticks within 48 hours, controls lice, prevents flea egg and larval development for up to 6 weeks, and is indicated for managing Flea Allergy Dermatitis. Available in four weight-band variants: Up to 10kg (MRP ₹300), 10–20kg (MRP ₹361), 20–40kg (MRP ₹464), and 40–60kg (MRP ₹558). Single pipette per pack. Prescription required.

Here's the honest value proposition: Fipronil + (S)-Methoprene is one of the most extensively tested and clinically validated tick and flea treatment combinations in the world. It has been the standard of care for canine ectoparasiticide management since Frontline Plus introduced it in the 1990s. The active ingredients are not a proprietary secret - they're established, well-understood, and their mechanism and safety profile are supported by decades of global veterinary use. Skyec Tick Free SpotOn delivers the same dual-active combination at a price point significantly lower than the original branded product, from one of India's trusted domestic veterinary pharmaceutical companies. For pet parents who need reliable, vet-approved, monthly tick and flea protection without the premium brand price tag, this is the straight-talking case for Tick Free SpotOn.

Marketed by SkyEC Drugs and Pharmaceuticals Pvt. Ltd., Survey No. 146/1A, 1B, Perumal Kovil Street, Tiruvallur Main Road, Thodukadu, Tiruvallur District, Tamil Nadu 602105.

Uses and Benefits of Skyec Tick Free SpotOn

• Adult flea elimination - kills adult fleas within 24 hours of application; reduces flea burden on the dog rapidly after the first dose
• Tick elimination including Indian brown dog tick - kills Rhipicephalus sanguineus (the most common Indian tick), Ixodes ricinus, Amblyomma americanum, and Dermacentor variabilis within 48 hours of application; prevents tick-borne diseases including Ehrlichiosis, Babesiosis, and Hepatozoonosis
• Lice (Trichodectes canis) control - effective against biting lice infestations
• Flea life cycle interruption for up to 6 weeks - (S)-Methoprene prevents flea eggs laid by fleas on the treated dog from hatching, and prevents flea larvae from developing into adult fleas, breaking the environmental reinfestation cycle
• Flea Allergy Dermatitis (FAD) management - eliminating fleas before they can bite prevents the allergic cascade in flea-sensitive dogs; indicated for managing FAD in conjunction with appropriate skin care
• Monthly protection for all breed sizes - four weight-band variants cover dogs from the smallest toy breeds to giant breeds above 40kg, with weight-calibrated pipette volumes ensuring the correct dose for each size category

Composition and Product Specifications

Active Ingredient 1	Fipronil IP 9.8% w/v
Active Ingredient 2	(S)-Methoprene 8.8% w/v
Drug Class	Phenylpyrazole ectoparasiticide (Fipronil) + Insect growth regulator (S-Methoprene)
Form	Topical spot-on liquid in pipette
Application Site	Base of neck / between shoulder blades
Pipette Volumes	0.67ml (≤10kg)
MRP	₹300 / ₹361 / ₹464 / ₹558
Protection Duration	30 days - reapply monthly
Schedule	Prescription required
For Use In	Dogs only - not for cats
Manufacturer	SkyEC Drugs and Pharmaceuticals Pvt. Ltd., Tamil Nadu

Side Effects of Skyec Tick Free SpotOn

• Tick Free SpotOn is well-tolerated by most healthy adult dogs when applied correctly. The safety profile mirrors Fipronil + (S)-Methoprene products globally, which have one of the longest track records in veterinary ectoparasiticide use
• Localised hair loss at application site - the most commonly reported reaction; temporary and self-resolving within 1 to 4 weeks; does not indicate product failure
• Mild skin irritation or redness at the application site - occasional; resolves spontaneously
• Hypersalivation and mild nausea - if the dog manages to groom the application site before drying, the carrier solvent tastes bitter and causes temporary drooling; not toxic, but preventable by applying at a location the dog cannot reach
• Temporary neurological signs - extremely rare at correct doses; the Fipronil mechanism selectively targets invertebrate GABA channels, but at overdose in small dogs, CNS effects can occur. Always use the weight-appropriate pipette - never apply a larger weight-band pipette to a small dog
• NEVER use on cats - Fipronil spot-on products in the dog formulation have caused serious adverse reactions in cats; always use the cat-specific formulation if treating a feline. This product is for dogs only

How to Use Skyec Tick Free SpotOn?

• Confirm your dog's exact body weight before selecting the correct pipette variant
• Remove the pipette from its packaging; hold it upright and snap or twist off the cap
• Part the fur at the base of the skull or between the shoulder blades until the skin is clearly visible
• Place the tip directly on the exposed skin and squeeze the entire contents of the pipette onto one spot - do not split across multiple spots
• Allow to air dry completely - do not touch the application site or allow children near it until fully dry (30 to 45 minutes minimum)
• Do not bathe your dog or allow swimming for at least 48 hours before or after application (72 hours preferred) - water strips the sebaceous oil layer that distributes the Fipronil across the coat
• Reapply once every 30 days - do not exceed monthly application or apply more frequently

Weight-Specific Pipette Guide:

Dog Weight	Correct Variant	Pipette Volume	MRP
Up to 10kg	≤10kg	0.67ml	₹300
10–20kg	10–20kg	1.37ml	₹361
20–40kg	20–40kg	2.68ml	₹464
40–60kg	40–60kg	Large pipette	₹558

How Does Skyec Tick Free Spot On Work?

• Fipronil - the primary ectoparasiticide: After application to the skin, Fipronil is absorbed into and stored in the sebaceous (oil-producing) glands beneath the skin surface. It is continuously re-released from these glands onto the skin and coat over the 30-day protection period. Ticks and fleas that crawl through the treated coat or bite the treated skin absorb the Fipronil, which then disrupts their GABA-gated chloride ion channels - the principal inhibitory neurotransmitter channel in invertebrate nervous systems. Channel blockade causes uncontrolled neural excitation, hyper-activity, paralysis, and death. This mechanism is selective for invertebrate GABA channels; mammalian GABA channels have a different structure, which provides the safety margin for use in dogs at therapeutic doses
• (S)-Methoprene - the insect growth regulator: Works on flea eggs and larvae rather than adult fleas. (S)-Methoprene mimics the natural juvenile hormone that flea larvae need at specific concentrations to complete their development into adult fleas. When flea eggs or larvae are exposed to (S)-Methoprene, the hormone signalling required for metamorphosis is disrupted - the larvae cannot mature into adults, and eggs cannot hatch normally. Fleas on a treated dog lay eggs containing (S)-Methoprene; those eggs cannot develop. This is what addresses the 95% of the flea population living in the environment (in carpets, bedding, floors) rather than only the 5% on the dog

Dr. Swathi Hareendran, MVSc (10+ years):

"Skyec Tick Free SpotOn contains the same Fipronil 9.8% and (S)-Methoprene 8.8% combination as Frontline Plus - both active ingredients at identical concentrations. Clinically, the mechanism is well-established: Fipronil stores in the sebaceous glands and is re-released continuously onto the skin and coat, killing ticks and fleas on contact; (S)-Methoprene is an insect growth regulator that prevents flea eggs from developing, addressing the environmental flea population. What this means in practice is that a pet parent choosing Tick Free SpotOn over the branded equivalent is not making a clinical compromise - they're making a cost decision. I recommend monthly application consistently, and I specifically caution against the misconception that a single application provides 3-month protection. Monthly reapplication is what the prescribing information specifies, and it's what maintains effective protection."

Safety Advice

• For dogs only - never apply to cats; Fipronil dog spot-on formulations can cause serious, potentially fatal adverse reactions in cats
• Use the weight-appropriate pipette - applying a higher weight-band pipette to a smaller dog constitutes a significant overdose
• Wash hands thoroughly after handling the pipette
• Keep away from children until the application site is fully dry
• Keep away from water bodies - the active ingredients are aquatic ecotoxins; prevent treated dogs from swimming in ponds, rivers, or streams for at least 72 hours after application
• Do not apply to broken, inflamed, or infected skin
• Not for use in sick, debilitated, or underweight animals without veterinary guidance
• Safe for use in pregnant and lactating female dogs at the recommended dose
• Safe for use in puppies from 8 weeks of age
• Store below 30°C away from direct sunlight; do not freeze; keep out of reach of children
• Schedule H - prescription required for purchase on Supertails

What If You Miss a Monthly Application?

• Apply the next pipette as soon as you remember and restart the 30-day schedule from that date
• Do not apply two pipettes at the same time to compensate - this doubles the applied dose and increases adverse reaction risk without improving protection
• The protection window of Fipronil decreases progressively after the 30-day mark; a lapsed application during India's monsoon peak - when tick and flea activity is highest - creates a meaningful unprotected window
• Set a recurring calendar reminder on the date of each application to prevent gaps

All Substitutes

Tick Free SpotOn contains the same active ingredients as Frontline Plus at the same concentrations. Here are confirmed live alternatives on Supertails across the Fipronil + S-Methoprene category and broader spot-on market:

Product	Active Ingredient(s)	Brand	Key Distinction
Frontline Plus Spot-On for Dogs (up to 10kg)	Fipronil 9.8% + S-Methoprene 8.8%	Boehringer Ingelheim	Identical active ingredients - the original branded formulation with the longest global track record
Frontline Plus Spot-On for Medium Dogs (10–20kg)	Fipronil 9.8% + S-Methoprene 8.8%	Boehringer Ingelheim	Identical actives at the same concentration - medium breed variant
Savavet Fiprofort Plus Dog Spot-On	Fipronil + S-Methoprene	Savavet	Another domestic generic at the same composition - Savavet brand alternative
Intas Nayflee Plus Spot-On for Dogs	Fipronil + S-Methoprene	Intas	Intas Pharmaceuticals branded generic - same composition, trusted large pharma company

Clinical equivalence note:

Frontline Plus (Boehringer Ingelheim), Fiprofort Plus (Savavet), Nayflee Plus (Intas), and Tick Free SpotOn (SkyEc) all contain Fipronil 9.8% + (S)-Methoprene 8.8% - the same active ingredients at the same concentrations. Clinical efficacy is equivalent across these products. The choice between them comes down to brand preference, availability, and price.

Quick Tips for Effective Monthly Use

• Always confirm your dog's current weight before each monthly application - this is especially important for growing puppies who may cross into the next weight band between doses
• Part the fur firmly enough to see skin before applying - the most common application error is applying onto fur rather than skin, which significantly reduces absorption and distribution
• For dogs who resist the application, have a second person hold the dog while you apply; a high-value treat offered immediately after application builds positive association with the process
• Do not allow other pets in the household to groom the treated dog for at least 24 hours post-application - the carrier solvent and active ingredients are bitter and can cause drooling in pets that lick the application site
• It is normal and expected to see more ticks and fleas moving actively on your dog's coat in the 24 to 48 hours after application - this is the die-off response, not a sign of treatment failure
• Pair monthly spot-on with a regular deworming routine - ticks and fleas are separate parasites from intestinal worms, and spot-on treatment does not substitute for deworming. Browse our dog dewormer collection
• For complete household protection, combine with a home environment tick spray - browse our tick and flea spray collection for environment-treatment options

Vets Also Recommend

• Browse the complete dog tick and flea treatment collection on Supertails - every format and active ingredient available
• Explore all spot-on tick and flea treatments across brands and weight categories
• Browse our dog preventive care collection for a complete monthly parasite prevention routine
• Pair with quarterly dog deworming - tick prevention and deworming are separate routines that both belong in a complete health plan
• Browse all dog pharmacy and medicines on Supertails
• For a personalised parasite prevention recommendation based on your dog's breed, lifestyle, and local tick burden, consult a vet on Supertails

Disclaimer: Supertails' sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Frontline Plus-Level Protection. Indian Brand Price.

Fipronil 9.8% + (S)-Methoprene 8.8%. The same two active ingredients at the same two concentrations as the world's most trusted tick and flea spot-on - from a trusted Indian veterinary pharmaceutical company, at a price that makes monthly protection accessible for every Indian dog parent. That's the Skyec Tick Free SpotOn offer: no compromise on the chemistry, just a sensible price.

Up to 10kg (MRP ₹300) | 10–20kg (MRP ₹361) | 20–40kg (MRP ₹464) | 40–60kg (MRP ₹558) - single pipette per pack.

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FAQs

Is spot-on good for ticks?

Yes - spot-on treatments like Skyec Tick Free are one of the most effective and convenient forms of tick prevention available for dogs. Tick Free spot-on contains Fipronil and (S)-Methoprene. Fipronil acts on chloride channels and their ligands, especially the GABA neurotransmitter, and kills fleas within 24 hours and ticks within 48 hours of application. Monthly application maintains continuous protection against the most common Indian tick species including the brown dog tick.

Does spot-on have side effects?

Skyec Tick Free SpotOn is well-tolerated by most healthy dogs at the correct dose. The most common reactions are localised - temporary hair loss at the application site and mild skin redness - both self-resolving. Hypersalivation can occur if the dog licks the wet application site before it dries; prevent this by applying between the shoulder blades where the dog cannot reach. Never apply a dog spot-on to cats, and always use the weight-appropriate pipette size to avoid overdosing.

How many times can I use spot-on?

Apply once every 30 days - this is both the minimum for continuous protection and the maximum safe application frequency. Do not apply more frequently than monthly regardless of tick burden. Do not reapply Tick Free SpotOn for 30 days. A common misconception among Indian pet parents is that one application provides 3-month protection - it does not. Monthly reapplication is what maintains effective protection throughout the year.

How long does spot-on take to work?

Fipronil kills fleas within 24 hours and ticks within 48 hours of application. In the first 24 to 48 hours after application, you may actually see more ticks and fleas on your dog's coat - they move to the surface as they die. This is the treatment working, not failing. Full coat distribution of Fipronil from the sebaceous glands takes 24 to 70 hours after application, after which the coat is uniformly lethal to ticks and fleas on contact.

How do you know if spot-on is working?

Several visible signs confirm the spot-on is working: you'll see ticks and fleas becoming visibly agitated and moving to the surface of the coat in the first 48 hours (die-off behaviour); within 48 to 72 hours the number of live ticks found on your dog should decrease significantly; your dog's scratching should reduce as the flea burden drops. Over the following weeks with monthly reapplication, re-infestation from the environment should also decrease as the (S)-Methoprene prevents eggs from hatching into new adult fleas.

Is Skyec Tick Free the same as Frontline Plus?

They contain the same active ingredients at the same concentrations - Fipronil 9.8% w/v and (S)-Methoprene 8.8% w/v. Frontline Plus is the original branded formulation by Boehringer Ingelheim; Skyec Tick Free SpotOn is the SkyEc-branded domestic generic equivalent. Clinical efficacy at the same dose is equivalent between products with identical active ingredient profiles. The primary practical difference is price - Tick Free SpotOn is priced significantly lower than Frontline Plus for the same active ingredients.

Can I use Skyec Tick Free SpotOn on my cat?

No - this product is for dogs only. The dog formulation of Fipronil spot-on products must never be applied to cats. Cats metabolise certain compounds differently from dogs, and the volume and concentration of the dog pipette is not safe for feline application. For cats requiring Fipronil + (S)-Methoprene spot-on protection, use the dedicated cat-specific Frontline Plus for Cats - the formulation and pipette volume are calibrated specifically for feline safety. Browse our cat tick and flea collection for appropriate feline options.